Recent studies suggest abnormal cannabinoid receptor type 2 (CB2) signalling in peripheral blood mononuclear cells (PBMCs) extracted from autistic children, implying the endocannabinoid system could be functionally involved in ASD-mediated immune impairments. Cannabinoid 1 receptors are present on neurons and microglial cells and additional research implicates these receptors in neuronal protection in a way which may represent a therapeutic target in ASDs. Research will be presented.